Alnylam’s First Profitable Year Tests Durability Of TTR RNAi Franchise

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Alnylam Pharmaceuticals (NasdaqGS:ALNY) has achieved its first full year of profitability in 2025, driven by the success of its TTR franchise and expanded Amvuttra indication. The company is also investing in a new RNAi manufacturing platform and forming new industry partnerships to broaden its RNA therapeutics portfolio. Key challenges include reliance on its TTR franchise and effective capital allocation for R&D and manufacturing to sustain its growth.

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