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MDGL Strengthens MASH Franchise With New Genetic Approaches
Madrigal Pharmaceuticals (MDGL) has expanded its metabolic dysfunction-associated steatohepatitis (MASH) pipeline through an exclusive global licensing agreement with Suzhou Ribo Life Science Co. Ltd., acquiring rights to six preclinical siRNA programs for an upfront payment of $60 million and potential milestone payments up to $4.4 billion. This move aims to develop innovative combination therapies with Madrigal’s approved drug Rezdiffra, the first MASH treatment, and other pipeline assets to enhance treatment outcomes for the serious liver disease. Madrigal plans to submit investigational new drug applications for the initial siRNA candidates in 2026 and evaluate them in combination with Rezdiffra.