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Roxadustat Achieves Orphan Drug Designation Milestone For Blood Disorder Treatment
FibroGen has received Orphan Drug Designation from the FDA for roxadustat, aimed at treating myelodysplastic syndromes (MDS). This recognition follows positive Phase 3 trial results showing significant transfusion independence, and it supports FibroGen's plans for regulatory submission by late 2025. The treatment is already approved for anemia in chronic kidney disease in various markets, marking an expansion into MDS.
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Understanding Point of Sale System Definition and Core Components
A point of sale system has become indispensable for modern retail operations. At its most fundamental level, a POS represents the convergence of hardware and software solutions designed to facilitate customer transactions. Whether managing a brick-and-mortar storefront or an e-commerce platform, und
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Roth IRA Withdrawals: What Actually Gets Taxed and What Doesn't
This essay explains the tax implications of withdrawing from a Roth IRA, detailing how contributions can be accessed tax-free and outlining the five-year rule for penalty-free earnings withdrawals, along with exceptions for qualified distributions.
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Bechtle Locks In Major Expansion Through Renewed Government Procurement Deals Valued At EUR 501 Million
Bechtle AG has strengthened its enterprise infrastructure business through renewed agreements with ProVitako, valued at up to 501 million euros. This deal enhances Bechtle's position in Germany's public sector, promoting growth in municipal IT services.
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What $952 Thanksgiving Celebration Actually Means for Your Hourly Wage
Thanksgiving spending is projected at a record high of $952 per household, equating to nearly 40 hours of pre-tax wages for those earning $50,000 annually. The budget covers food, travel, and decorations, with many Americans attending multiple events, inflating costs. Strategic cuts in food, decorations, and travel can reclaim significant funds, emphasizing the importance of being financially mindful during the holidays.
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Is Opendoor Technologies a Buy or a Bluff? What the Numbers Tell Us
Opendoor Technologies (NASDAQ: OPEN) has become the darling of retail traders and social media investors, with shares surging more than 370% year-to-date. Behind the hype, however, lies a company struggling with fundamental operational challenges that should give cautious investors pause.
The
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Understanding Indirect Taxes: Why Lower-Income Earners Bear a Heavier Load
When you buy a product at a store or pay for a service, you're likely paying more than the base price suggests. The difference comes from indirect taxes—levies imposed on goods and services rather than directly on your income or profits. Unlike income taxes withheld from your paycheck, indirect taxe
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Six-Figure Careers: Do the High Salaries Justify the Mental Toll?
When people envision earning six figures, they often picture the payoff without considering the price. The truth is more nuanced: lucrative careers frequently come with intense pressure, demanding schedules, and high-stakes decision-making. But here's the paradox—some professionals thrive in
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## Can Shiba Inu Survive Without a Price Revival?
The meme coin landscape has exploded with projects ranging from cute shiba puppies to absurd creatures. Yet only a handful have achieved meaningful scale. **Shiba Inu (CRYPTO: SHIB)** and **Dogecoin (CRYPTO: DOGE)** stand out, both boasting market capitalizations exceeding $2 billion. But does longevity in the top 50 mean genuine value?
### The Price Collapse Story
Since its 2020 launch, **Shiba Inu** has experienced a dramatic reversal. The token is currently trading down more than 90% from its peak, with losses extending roughly 75% over the
SHIB-0.59%
DOGE-2.33%
LINK0.25%
BTC1.07%
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Bull Market vs Bear Market: Understanding Market Cycles and What They Mean for Your Portfolio
The Core Difference: Two Opposite Market Conditions
Stock markets move in cycles, and investors often describe these movements using two contrasting terms: bull markets and bear markets. These aren't just colorful Wall Street slang—they represent fundamentally different economic and market
IN1.65%
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Ontario Securities Commission Imposes Trading Restrictions on Dye & Durham Over Filing Non-Compliance
Dye & Durham Limited faces serious regulatory consequences after failing to meet critical financial disclosure deadlines, leading to a failure-to-file cease trade order from the Ontario Securities Commission, escalating previous restrictions on its executives.
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Why Medical Device Giant Intuitive Surgical Deserves Your Attention — Despite Recent Headwinds
When heavyweight investors like Izzy Englander's Millennium Management and Cathie Wood's Ark Invest both hold the same stock, it's worth taking notice. Intuitive Surgical [(NASDAQ: ISRG)](/market-activity/stocks/isrg) is precisely such a case, signaling strong conviction from two of Wall Street's
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Ceribell's AI Seizure Detection Gets FDA Nod: What This Means For Neonatal Care
Ceribell, Inc. has achieved FDA clearance for its Clarity algorithm, the first seizure detection technology for all ages, addressing the critical need for timely neonatal seizure monitoring and positioning the company for market success.
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The Rule of 55: Your Guide to Accessing 401(k) Funds Early Without Penalty
The essay explains the early withdrawal penalty for 401(k) plans and introduces the Rule of 55, allowing penalty-free withdrawals if you leave your job at 55 or older. It highlights the importance of understanding this rule, strategic considerations for early withdrawals, and alternative income options to preserve retirement savings.
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What's Driving Silver's Explosive 2025 Rally—And What Comes Next in 2026?
Silver ounce prices have soared to four-decade peaks throughout 2025, with the precious metal climbing above US$64 per ounce in mid-December following fresh rate cuts. This surge reflects a confluence of forces: structural supply shortfalls, surging industrial appetite from renewable energy and AI i
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Why Silver's 2026 Outlook Is Reshaping the Precious Metals Landscape—And What Investors Need to Know
Silver just wrapped up one of its strongest years on record, vaulting past US$64 per ounce in December 2025—a level unseen for more than four decades. This explosive rally reflects a convergence of structural imbalances and macro forces that are likely to remain center stage throughout 2026. Here's
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Maximize Your RMD Reinvestment Strategy: Smart Ways to Deploy Cash When You Don't Need It Right Away
Why Your RMD Doesn't Have to Sit Idle
When required minimum distributions (RMDs) hit your bank account at age 73 (or 75 starting in 2032), you face a choice: let the cash accumulate or put it to work immediately. Most retirees overlook a critical opportunity—you can reinvest that mandated
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Has Lululemon's Stock Finally Hit Bottom? Decoding the Q3 Earnings Surprise
The Stock's Sharp Decline Sets the Stage
Lululemon Athletica Inc. (LULU) has experienced a dramatic reversal from its decade-long premium performance. Down 50% year-to-date, the athletic apparel maker now faces a critical test with its Q3 earnings report arriving on Thursday, December 11th after m
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Nyxoah's Genio Scores in Europe: The Sleep Apnea Device Shaking Up Patient Options
Nyxoah SA has launched Genio, a novel implant therapy for obstructive sleep apnea (OSA), in the Netherlands. This leadless, battery-free device is designed to be user-friendly and performs well even for patients with complex conditions. The company aims for broader European expansion following successful regulatory approvals. Investor interest is growing as Nyxoah shifts focus to revenue generation.
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How to Choose the Right Portfolio Management Tools for Your Investment Strategy
Making informed investment decisions requires a clear view of your complete financial picture. Portfolio management tools serve as essential companions for investors who want to track performance, evaluate risk exposure, and fine-tune their asset allocation strategy. This guide examines today's
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